The Three Rs – Replacement, Reduction, and Refinement – are successfully applied in scientific research in a range of scenarios including husbandry, care practices and experimental settings. They provide a framework for considering important ethical issues when planning an animal experiment. The main objectives of the Three Rs are to perform humane research on animals and to impact positively on the quality of research. A crucial role to the success of these achievements is due to proper experimental design.
Fondazione Guido Bernardini